Sedating an

They also act on muscarinic, alpha-adrenergic, and serotonin receptors.

This means that first-generation antihistamines are more likely to cause side effects such as sedation, dry mouth, dizziness, low blood pressure, and a rapid heart-beat.

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If your doctor gives you the medicine to swallow, you will feel the effects after about 30 to 60 minutes.

Your breathing will slow and your blood pressure may drop a little.

Antihistamines are very good at relieving symptoms of an allergic reaction, such as: First-generation antihistamines were developed more than seventy years ago and are still in widespread use today.

They act on histamine receptors in the brain and spinal cord and in the rest of the body (called the periphery).

Histamine-1 receptors are also found in the brain and spinal cord, and stimulation of these receptors makes you more awake and alert.

Sedating antihistamines oppose the effects of histamine on H1 receptors in your brain, which is why they cause sedation and drowsiness.

Also reviewed by David Zieve, MD, MHA, Medical Director, Brenda Conaway, Editorial Director, and the A.

Antihistamines are a class of agents that block histamine release from histamine-1 receptors and are mostly used to treat allergies or cold and flu symptoms, although some first-generation antihistamines may also be used for other conditions.

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